Tg(Trp53A135V)L3Ber

The transgene contains the mouse transformation related protein 53 promoter and an allele of the mouse Trp53 gene that carries a point mutation in codon 135 (GCG to GTG), resulting in an alanine to valine substitution. The Trp53 promoter drove high levels of transgenic expression in the spleen, thymus, and lymph nodes. Transgenic expression was also reported in the ovaries. Little or no expression was reported to have been observed in the liver and lungs of these mice. (J:19870)