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This transgene contains the mouse Trp53 (p53) promoter and an allele of the Trp53 gene that carries a point mutation in codon 135 (Ala135Val). Analysis showed the Trp53 promoter to drive high levels of expression in the spleen, thymus, lymph nodes, and ovaries. Transgenic expression was also detected in the lungs, liver, kidney, testis, and brain, while low levels were detected in skeletal muscle. Expression was undetected in the heart and blood. (J:19870)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
