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An 11 kb construct containing a rearranged Igh-V region (a allotype) encoding a 4-hydroxy-3-nitrophenenacetyl antibody under the control of the Igh-V promoter was generated using molecular techniques. The construct was designed such that the exons encoding the Igh-6 secretory isoform were included while the exon encoding the membrane isoform was deleted. FACS analysis confirmed a lack of transgenic surface expression, while IgM comprised of transgenic Igh-6 was detected in the serum. (J:80656)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
