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The chicken Chrna1 promoter was used to drive expression of Torpedo californica (fish) Chrna1 cDNA in muscle tissue. The transgene construct included a spliceable intron and polyadenylation sequences from the rabbit beta globin gene. Only one founder line was generated. Transgene expression was verified by RT-PCR analysis with strong expression observed in muscle tissue. Very low levels of transgene expression was observed in the brain and thymus. (J:80567)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
