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The Lck promoter was observed to drive expression in the T-cell containing tissues including the thymus, spleen and lymph nodes. The highest levels of expression were observed in thymic tissue. Immunohistochemical analysis of T-cell containing tissues confirmed overexpression of a dominant negative peptide consisting of the DNA binding domain (residues 1 through 376) of the human ADP-ribosyltransferase protein. ADP-ribose polymerization was undetected in thymocytes treated with MNNG, a monofunctional alkylating agent, indicating inhibition of the enzymatic activity of the endogenous protein. (J:80883)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
