Log In|Sign Up
EN
The core region of a Cd4 cis-regulatory element that silences expression of the endogenous locus during T cell development (S4) was deleted from intron 1 via homologous recombination of a targeting construct lacking nucleotides 167 through 257. A single loxP site was left upstream of the deleted region, however analysis of a control allele indicated that the loxP site did not affect normal expression. Flow cytometric analysis of peripheral blood lymphocytes obtained from mutant mice showed no silencing of Cd4 expression. (J:80576)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
