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Sequence encoding the precursor protein signal sequence was replaced with a cassette containing beta-galactosidase and neomyicin resistance genes. Transcript was undetected by Northern blot analysis of intestinal and brain samples obtained from homozygous mutant mice. Similarly, radioimmunoassay of HPLC-fractioned brain extracts and immunohistochemical analysis of brain sections indicated an absence of normal protein. Expression of the beta-galactosidase gene was not detected by staining. (J:80590)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
