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All of exon 1 and a portion of exon 2 were replaced by a cassette inserted by homologous recombination and containing lacZ and neo. In addition to deleting endogenous sequence, the insertion of the cassette shifted downstream sequence out of frame. Expression analysis of embryonic fibroblasts derived from homozygous mutant mice indicated an absence of both transcript and protein, even after serum stimulation. Expression of lacZ was determined to be driven by the endogenous promoter. (J:80618)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
