Log In|Sign Up
EN
Human APP sequence encoding amino acids 591 through 695 was adjoined to the human NEFL regulatory sequences as well as the first exon. Northern blot analysis showed expression of the amyloid derived transcripts, approximately 900 nt long, at levels similar to the endogenous App in the brains of transgenic mice. Western blot analysis using an antibody raised against the beta-amyloid peptide showed a pattern of bands that correlates with carboxy terminal fragments identified in human brain. Three lines were established. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:80639)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
