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A hypomorphic allele was generated by the insertion of a cassette containing tTA, PGK-neo, and tetO immediately upstream of the start codon. While expression of tTA was not detected, putatively due to an influence of the PGK promoter, Western blot analysis of homozygous mutant mice showed that the presence of the cassette reduced protein levels by approximately 90% in the striatum. (J:67549)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
