LoxP sites and a floxed neo cassette were inserted on either side of an exon by homologous recombination. Transient expression of cre recombinase in correctly targeted cells removed the floxed neo cassette, leaving behind a loxP-flanked exon. (J:80427)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count