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The transgene consists of a Camk2a promoter fused to a Fyn isoform B cDNA carrying a TAT to TTT nucleotide substitution at codon 531. Camk2a drives expression in forebrain neurons late in development. This mutation renders Fyn constitutively activated. Transgene expression in the brain was confirmed by Northern blot, RNase protection assay, RT-PCR, and in situ hybridization. (J:59490)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
