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A dominant negative form of mouse Nfat5 consisting of only the binding domain (amino acids 267-543) was cloned into a human CD2 expression vector and used as the transgene. The CD2 promoter is active in the thymus and mature peripheral T lymphocytes. Western blot analysis confirmed transgene expression in the thymus and spleen. (J:80066)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
