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The transgene consists of a mouse Hba-x promoter and an Hras1 coding sequence carrying activating mutations G12R (glycine to arginine) and A59T (alanine to threonine). The Hras1 sequence is followed by an SV40 polyadenlyation signal. RNase protection assay detected transgene expression in day 12 embryonic blood, hematopoietic fetal liver, and placenta. Low levels of transgene expression was also detected in adult bone marrow. (J:55016)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
