Tg(Hba-x-v-Ha-ras)TG.ACLed

The transgene consists of a mouse Hba-x promoter and an Hras1 coding sequence carrying activating mutations G12R (glycine to arginine) and A59T (alanine to threonine). The Hras1 sequence is followed by an SV40 polyadenlyation signal. RNase protection assay detected transgene expression in day 12 embryonic blood, hematopoietic fetal liver, and placenta. Low levels of transgene expression was also detected in adult bone marrow. (J:55016)