Hoxd13, Hoxd12, and regions X and XI were deleted via trans-allelic meiotic recombination (TAMERE). The deletion was accomplished by recombination of a single loxP site in the intergenic region between Evx2 and Hoxd13 (Evx2/Hoxd13tm1.1Ddu; also contains a stop codon in the first exon of Evx2, at bp 110) and a single loxP on the opposite chromosome 303 bp upstream of a 261 bp deletion of region X (Hoxdtm4.1Ddu). (J:80084)
Basic Information
Intergenic deletion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count