Translation of both the Evx2 and Hoxd13 loci was disrupted by the insertion of stop codons at base pairs 110 and 58 of the respective open reading frames. In addition, the targeting construct contained a floxed neo cassette inserted into the intergenic region as well as 153 bp deletion of Hoxd13. (J:37211)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion, Nucleotide substitutions
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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