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The transgene consists of a fusion between the MMTV-LTR and a genomic Nras sequence from exon 1 to part of exon 6. The MMTV-LTR was used to drive transgene expression. High levels of expression was observed in the salivary gland, mammary gland, and Harderian gland. Intermediate levels of expression was observed in the lung, prostate, testis, and ovary. Low levels of expression was detected in thymus, brain, muscle, skin, bone marrow, kidney, gut, and heart. Transgene expression was verified by Northern blot and RNase protection assay. (J:72258)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
