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A tet transactivator gene under the control of a mouse Prnp promoter was used for the transgene. The mouse Prnp promoter targets transgene expression to the brain. High levels of transgene expression was observed in the cortex and hippocampus, and lower levels were observed in thalamic, hypothalamic, and brainstem regions via mRNA in situ hybridization. (J:50359)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
