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Exon 5, which encodes amino acids 94 through 167, was replaced by the insertion of a neomycin selection cassette. The deleted region encompassed portions of repeats 2 and 3 that are involved in DNA binding. Whereas this allele was observed to be homozygously lethal, similar amounts of protein were detected by Western blot analysis of wild-type and heterozygous mice. (J:57999)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
