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The transgene is composed of a mouse Thy1 promoter, a human alpha synuclein (SNCA) cDNA encoding an alanine to proline substitution at amino acid 30 (A30P), and exon 4 of mouse Thy1, which contains polyadenylation signals. The A30P mutation is found in human patients with severe early onset Parkinson disease. Transgene expression is detected in the spinal cord and most areas of the brain except the substantia nigra. (J:64205)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
