Tg(GFAP-SRC)2Aag

The transgene was constructed by insertion of a viral SRC cDNA sequence from the Schmidt-Ruppin strain into exon 1 of GFAP. The GFAP promoter drives expression of the transgene in astrocytes of the brain. RT-PCR analysis of brain RNA from transgenic animals confirmed expression of the transgene. Transgene expression was also detected in lung, thymus, spleen, and gonads. (J:40335)