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The transgene consists of a human GFAP promoter, an intervening floxed lacZ cassette, and a mutant SV40 T antigen sequence. The 2.2 kb fragment of human GFAP was used to direct transgene expression in central nervous system cells of the astrocyte lineage.The SV40 sequence contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. Immunohistochemical staining of brain sections from transgenic animals showed expression of lacZ and not SV40 T121, as expected. (J:77132)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
