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Homologous recombination of a construct containing lacZ and neo resulted in the deletion of a portion of exon 3 and all of exons 4 through 7. The targeted region encoded amino acids 200 through 1380, corresponding to the protein kinase A and leucine zipper domains. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney, liver, and testis tissues. Beta-galactosidase staining showed the expression pattern of lacZ to be similar to that of the endogenous gene. (J:74982)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
