Glis1^tm1Mnks

840 bp of exon 2, encompassing the start codon and sequence encoding the first 2 zinc finger domains, were replaced with a lacZ-neo cassette. Normal transcript was undetected by Northern blot analysis of homozygous mutant mice. Comparison with in situ hybridization results indicated that the lacZ expression pattern was similar to that of the endogenous gene. (J:80052)