Ccr5^tm1Brv

A neomycin selection cassette into exon 2 via homologous recombination replaced sequence encoding all 7 transmembrane domains. Whereas mRNA transcribed from other chemokine (C-C motif) receptor loci was shown to be present at normal levels, endogenous transcript was undetected in homozygous mutant mice by Northern blot analysis. The expression of other CC-chemokine receptor genes, Ccr1, Ccr2, Ccr3, and Ccr4, was not affected. (J:46941)