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Expression of human sequence encoding MCP in the mouse was achieved using the mouse Acp5 promoter region, active in cells of the osteoclast lineage. The transgenic sequence encoded the largest isoform that exhibits a high level of expression in human osteoclasts (MCP-C1). Founder mice contained approximately 3 copies of the transgenic construct. (J:71933)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
