Socs6^tm1Dlk

The entire open reading frame was replaced with a cassette containing lacZ and neo inserted at the enodgenous start codon by homologous recombination. Neither transcript nor protein was undetected by Northern or Western blot analyses of a variety of tissues obtained from homozygous mutant mice. Expression of beta-galactosidase was driven by the endogenous promoter. (J:77039)