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The endogenous gene was disrupted by the insertion of a cassette containing human vimetin (VIM) sequence followed by growth hormone sequence and PGK-neo. Though the VIM sequence was inserted at the endogenous start codon, the transgene was not expressed. Northern and Western blot analyses indicated an absence of both endogenous transcript and protein in homozygous mutant mice. (J:25763)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
