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The endogenous 3' UTR was replaced with a bovine growth hormone 3' UTR. The bovine sequence contains an identical polyadenylation hexanucleotide but lacks a dendritic localization signal. In situ hybridization of mutant brain sections indicated that dendritic localization was disrupted. Quantification of the hybridization results showed reduced expression levels in hippocampal cell bodies (approximately 85.3% of wild-type). (J:79713)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
