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The entire bovine adrenergic receptor kinase, beta 1 (ADRBK1) coding region was ligated to a 5.5 kb fragment of the murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Overexpression of the transgenic protein was detected by Western blot analysis of heart extracts. Biochemical assays showed that kinase activity was approximately 3 times greater in heart extracts from transgenic mice than from wild-type mice. The Myh6 promoter drives expression in myocardial tissue. (J:37034)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
