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The majority of exons 1 and 2, as well as the intervening intron, were replaced with a construct containing GFP followed by neo. GFP was inserted immediately downstream of the endogenous start codon. Northern blot analysis of heterozygous mutant mice showed transcript levels to be reduced by approximately 50% in brain, heart, kidney, and skeletal muscle samples. (J:79609)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
