The majority of the coding region including the ETS domain was replaced by a neomycin selection cassette inserted by homologous recombination. RT-PCR analysis of bone marrow cells isolated from homozygous mutant (female) mice showed a lack of transcript. The absence of protein was demonstrated by Western blot analysis of thymic lysates. (J:79568)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
Insertion, Intragenic deletion
--
1
3
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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