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A modified Map3k8 cDNA in which viral LTR sequence replaced exon 8 was adjoined to a lck proximal promoter, active in thymocytes. The transgene encodes a truncated protein which lacks the 23 carboxy terminal residues, resembling the truncated protein which is produced after integration of the Moloney murine leukemia virus (MoMLV) at the Map3k8 locus. Expression analysis confirmed the expression of a truncated protein. (J:39450)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
