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Embryonic stem cells carrying a deletion for the HsA enhancer element (Rr282726) were subjected to gene targeting to replace the Ecgamma 1 enhancer element (Rr275254) with a loxP site flanked neomycin resistance gene cassette. Correctly targeted cells, in which the Ecgamma 1 enhancer element was mutated on the same chromosome as the HsA deletion, were transfected with a cre expression plasmid to remove the floxed neo cassette. (J:75624)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
