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Missense mutations at codons 207 and 208 were introduced at the endogenous locus via homologous recombination. The mutations were designed to substitute a glutamate (207) and glycine (208) with alanine residues. A floxed neo cassette was integrated upstream in intron 2 for selection. Mice carrying this allele were used to generate Esr1tm1.1Lja. (J:79228)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
