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The transgene consists of the tyrosine kinase domain of human RET fused to a portion of the human AKAP1 gene, followed by sequences from human beta globin. The fusion gene is found in certain papillary thyroid carcinomas as a result of chromosomal rearrangement. Mouse Hoxb7 promoter sequences drive transgene expression throughout the uretic bud branches. (J:52988)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
