Tg(Hoxb7-RET/AKAP1)1Cos

The transgene consists of the tyrosine kinase domain of human RET fused to a portion of the human AKAP1 gene, followed by sequences from human beta globin. The fusion gene is found in certain papillary thyroid carcinomas as a result of chromosomal rearrangement. Mouse Hoxb7 promoter sequences drive transgene expression throughout the uretic bud branches. (J:52988)