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The 4 signal transducer and activator of transcription (STAT) sites in exon 18 were deleted by homologous recombination of a construct containing two missense mutations (disrupting the first site) and an IRES-neo cassette (replacing the other 3 sites). The missense mutations were at codons 765 (tyrosine to phenylalaine) and 768 (glutamine to alanine). A nonsense mutation was engineered at codon 769, immediately preceding the IRES-neo cassette. Transcription of the targeted allele was verified by Northern blot analysis. (J:79555)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
