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A ROSA Beta-geo gene trap vector randomly integrated into an intron between the two coding exons of the endogenous locus. Wild-type mRNA was undetected by RT-PCR analysis of total RNA obtained from homozygous mutant testes tissue. Transcript levels produced by adjacent genes, Madcam1 and Cdc34, were normal, indicating that they were unaffected by the insertion. The expression pattern of the integrated beta-galactosidase sequence was determined to be similar to that of the endogenous gene as determined by in situ hybridization. (J:79292)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
