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The endogenous locus was modified via homologous recombination and subsequent in vitro cre-mediated excision to generate a floxed version of Ightm2Cgn. The region flanked by single loxP sites contained the inserted variable region derived from a 4-hydroxy-3-nitrophenyl acetyl binding antibody (B1-8) as well as the Igh intron enhancer (Emu or Rr150). Flow cytometry verified cell surface expression on peripheral B cells obtained from heterozygous and homozygous mice. (J:79299)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
