The gene was disrupted by insertion (knock-in) of a GFP-neo cassette into the coding sequence. RT-PCR analysis of bone marrow RNA confirmed the absence of Rag1 gene expression in homozygous mutant animals. Instead the mutant animals produced GFP transcripts. (J:79416)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
Insertion
--
1
7
44

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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