Log In|Sign Up
EN
Sequence encoding lyusine-proline-glutamine (residues 1505-1507) were replaced by a single loxP site via homologous recombination followed by in vitro cre mediated excision. This deletion was designed to emulate long-QT3 (LQT3) syndrome, which results in the prolongation of the electrocardiographic QT interval. Quantitative RT-PCR and Western blot analysis confirmed that both transcript and protein levels produced by the targeted allele were comparable to wild-type expression. (J:71542)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
