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A single loxP site remained in place of exon 3 after an upstream floxed neo cassette and downstream loxP site were recombined by transient expression of cre recombinase in targeted ES cells. The mutation results in deletion of the transmembrane domain and the GS domain required for protein function. Northern blot analysis using a full-length cDNA probe did not detect transcripts in endothelial cells from homozygous mutant embryos. (J:68770)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
