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Exons 1 through 9, encoding the first 490 amino acids, were deleted by homologous recombination of floxed selection genes followed by cre mediated excision in male germ cells. Targeting was done in PC3 ES cells which are homozygous for a protamine-cre transgene, Tg(Prm-cre)70Og, which expresses Cre recombinase only in halpoid spermatids. Normal protein was undetected by Western blot analysis of thymocytes obtained from homozygous mutant mice. (J:79133)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
