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The oocyte-specific exon 1o and the proximal promoter region were deleted and replaced with a floxed HSV-tk-PGK-neo cassette. The resistance cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Immunohistochemical analysis of ovary sections from homozygous mutant animals confirmed the absence of gene expression in mutant oocytes. (J:68455)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
