Oprd1^tm1Jep

Exon 2 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice using an antiserum directed against the amino terminal. Furthermore, an absence of ligand binding was determined via autoradiographic analysis of radiolabeled ligands that preferentially bind to the pharmacologically defined receptors, delta1 and delta2. (J:57886)