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Sequence encoding the third helix of the homeodomain was disrupted by the insertion of a lacZ reporter cassette. The inserted cassette contained stop codons in all three reading frames, precluding the translation of the endogenous carboxy terminal, which is involved in transactivation. Comparisons with wild-type in situ hybridization results showed that the expression of lacZ was similar to the endogenous expression pattern. (J:65759)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
