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This transgene contains the mouse Defcr2 (defensin related cryptdin 2) promoter region (-6500 to +34) and the wild-type allele of the SV40 large T antigen (Tag) gene. Expression of the transgene is targeted to neuro-endocrine cells of the prostate gland. The Defcr2 promoter was originally observed to drive expression in Paneth cells of intestinal crypts and subsequently in prostatic epithelium. Eight lines were established but the references do not distinguish between them. Data may have been pooled from more than one line. (J:43025, J:51704)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
