Log In|Sign Up
EN
The transgenic construct consisted of a CAG promoter (chicken beta actin promoter and CMVIE enhancer) followed by a floxed neo-polyA region upstream of the human CCND1 coding region. CCND1 expression under the control of the CAG promoter only occurs after cre excision of the floxed neo-polyA cassette. Five transgenic founder lines were produced. Cre mediated recombinations were confirmed in three lines, two carrying five copies of the transgene and one carrying 10 copies. This line has five copies and was stably transmitted to the next generation. (J:75626)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
