Nucleotides 1745 to 2033, encompassing portions of exons 10 and 11 and the intervening intron, were replaced with a neomycin selection cassette. RT-PCR and sequence analyses identified an aberrant transcript containing the first 569 codons of the endogenous gene fused to 75 neo codons. This transcript was undetected by Northern blot analysis, indicating that it was unstable. (J:74077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
37
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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