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The endogenous locus was targeted with a construct containing human cDNA derived from t(8;21), a translocation observed in leukaemic cells of patients with the M2 subtype of acute myeloid leukemia (AML). The human sequence included 62 bp of exon 4 and all of exon 5 of RUNX1 fused to a portion of CBFA2T1. This RUNX1-CBFA2T1 sequence was fused in frame 95 bp into exon 4 of the endogenous murine gene. Hybrid transcript was detected by RT-PCR analysis of differentiated ES cells. (J:79160)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
